Objective      To investigate the efficacy of minimally invasive gallbladder-preserving cholecystolithotomy in the treatment of gallstone and determine its effect on the quality of life of patients. Methods      A total of 158 patients with gallbladder stones who admitted in our department from January 2014 to December 2015 were recruited in this study and assigned into endoscopic minimal invasive cholecytolithotomy with gallbladder preserving (EMIC group

n=71) and laparoscopic cholecystectomy (LC group

n=87) according to their surgical approaches. The surgical efficacy

quality of life after treatment and complication occurrences were compared between the 2 groups. Results      The amount of bleeding

operation time

first exhaust time and length of hospital stay were significantly lower in the patients of EMIC group than those of group LC  (P0.05). After the treatment

the EMIC group had obviously higher scores in physiological functions

subjective symptoms

psychological state

daily life and social activities when compared with the LC group (P0.05). The incidence of postoperative complications was 7.04% (5/71) in the EMIC group

and 18.39% (16/87) in the LC group

with the statistically difference between the 2 groups (P0.05). Conclusion      EMIC with gallbladder preserving is of many advantages

including small trauma and high safety for the patients with gallstone

quick recovery and reservation of the physiological functions of the gallbladder

improvement of quality of life after surgery

and lower postoperative complication occurrence. So it is worth of clinical application.