Objective      To investigate the risk factors for early hypocalcemia after parathyroidectomy in the patients with uremic secondary hyperparathyroidism. Methods      One hundred and sixteen uremic patients with secondary hyperparathyroidism and underwent total parathyroidectomy with autotransplantation in the Qianfoshan Hospital and General Hospital of Jinan Military Command from July 2013 to August 2016 were enrolled in the study. According to the post-operative serum calcium (Ca) levels within 24 h

the patients were divided into the normocalcemia group (n=33

＞2 mmol/L) and the hypocalcemia group (n=83

≤2 mmol/L). A stepwise logistic regression analysis was used to analyze the age

vintage of dialysis

pre-operative Ca

pre-operative hemoglobin

pre-operative alkaline phosphatase and preoperative parathyroid hormone to determine the risk factors for early hypocalcemia. Results      Logistic regression analysis indicated that pre-operative hypocalcemia (95%CI: 0.11～0.37

P=0.001)

high levels of alkaline phosphatase (95%CI: 0.71～0.93

P0.001) and parathyroid hormone (95%CI: 0.58～0.85

P=0.003) were independent risk factors of early hypocalcemia after parathyroidectomy. Conclusion      Pre-operative hypocalcemia

and high levels of alkaline phosphatase and parathyroid hormone are independent risk factors for early hypocalcemia after parathyroidectomy.