Ba Junqiang,Gao Hongjiao,Xu Xianglin,Jiang Chengyan,Shi Rong,Peng Jie,Li Jindie.Correlation of exercise hypertension with type 2 diabetes mellitus and insulin resistance[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(20):2279-2282.
Ba Junqiang,Gao Hongjiao,Xu Xianglin,Jiang Chengyan,Shi Rong,Peng Jie,Li Jindie.Correlation of exercise hypertension with type 2 diabetes mellitus and insulin resistance[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(20):2279-2282.DOI:
Objective To explore the correlation of exercise hypertension(EH) with type 2 diabetes mellitus (T2DM) and insulin resistance in the patients. Methods A total of 109 cases of in- and out-patients diagnosed with T2DM who were admitted at the department of endocrinology in the first people’s hospital of Zunyi from August 2010 to July 2013 were randomly recruited as the treatment group. All patients had normal resting blood pressure. Forty-three cases of age- and gender-matched healthy volunteers were taken as control group. Bruce exercise program was used for secondary symptoms of restrictive exercise test.Incidence of EH in T2DM patients and control group was compared.Insulin resistance was assessed by homeostasis model assessment-insulin resistance (HOMA-IR) test.The correlation of EH with insulin resistance
glycosylated hemoglobin
age
and blood lipid in T2DM patients was assessed by using independent sample t test and single factor logistic regression analysis. Results Compared with control group
the systolic blood pressure changed significantly before and after the exercise test in T2DM group. Also
the incidence of EH in T2DM patients were significantly higher (P0.05). The HOMA-IR index of the EH group was significantly higher than the non-EH group(P=0.013) by t-test. The results of single factor logistic regression analysis showed that the HOMA-IR index was included in the equation
suggesting that insulin resistance might be a risk factor of EH occurrence
with odds ratio (OR) of 1.48 and corresponding 95%confidence interval (CI)of (1.03~2.12). Conclusion T2DM can increase the risk of developing EH. Patients with EH may have higher insulin resistance compared to those T2DM patients without EH.