Objective     To investigate the relative risk factors for coronary artery instent restenosis (ISR) via a retrospective analysis of patients with coronary angiography after percutaneous coronary intervention (PCI). Methods     A total of 1 136 patients (835 males and 301 females

at an average age of 61.61±12.32) who undergoing coronary stent implantation in our cardiology department of the first affiliated hospital from January 2007 to May 2015 and then received coronary angiography in 8 to 12 months’ follow-up were subjected in this study. According to the results of coronary angiography

they were divided into ISR group (n=72) and non-ISR group (n=1 064). Risk factors for cardiovascular diseases

clinical complications

medications and relevant parameters of interventional therapy were recorded in both groups and analyzed for the relevant factors causing ISR. Results      The incidence of ISR was 6.3% in the study. There were significant differences in smoking

diabetes

dyslipidemia

hypertension

poor medication compliance

long and multi-vessel lesions

diameter and length of stent

and minimal luminal diameter (MLD) between the ISR group and the non-ISR group (P0.05). And also

significant difference was found in the percentage of the patients with long-term regular uses of aspirin

clopidogrel and large dosage satins between the ISR group and non-ISR groups (P0.05). Conclusion      Post-procedure restenosis in the patients with coronary heart disease after PCI is the result arose from multiple clinical factors

and associated with uncontrolled cardiovascular risk factors

antiplatelet therapy and statins compliance as well as the characteristics of implanted lesions. Well control of the risk factors and improved medication compliance maybe effectively reduce the rate of ISR.