Objective    To determine the effect of strengthened or weakened emotional processing on cognitive control in individuals with subthreshold depression.  Methods     Sixteen participants with subthreshold depression were screened out from 379 students from Chongqing universities with Beck depression inventory (BDI-2) and selfrating depression scale (SDS)

and 22 normal individuals were subjected as healthy control. BrainAmp MR was employed to acquire the simultaneous EEG/fMRI of all participants under emotioninterference task at the same time.  Results     ①The reaction times of depressive individuals were significantly longer than healthy controls when their emotional processing was strengthened (attended to the sad faces

or ignore the happy faces

P0.01). When the emotional processing was strengthened (attended to happy or sad faces)

depressive individuals’ accuracies were significantly lower than healthy controls (P0.01). ②When the emotional processing was weakened (attended or ignored the neutral faces)

depressive individuals’ reaction times and accuracies were significantly longer and lower than the healthy controls (P0.01). ③ Under the total strengthened emotional processing

the amplitudes of N450 was smaller in the depressive individuals (F=3

463

P=0.002). While under the partial strengthened emotional processing (happy faces)

the amplitudes of P300 was significantly larger than healthy controls (F=2.128

P=0.043)

and that of LPC was more smaller (F=2.171，P=0.04). And

for sad face

the latencies of N450 (F=2.462

P=0.021) and LPC (F=2.659

P=0.013) were significantly shorter. ④The amplitudes of N200 (F=2.47

P=0.021) and N450 (F=2.657

P=0.014) were smaller than healthy controls under partial weakened emotional processing (neutral face)

and the latency of N450 was shorter (F=2.653

P=0.014).   Conclusion     No matter emotional processing is strengthened or weakened

the cognitive control is significantly damaged in the individuals with subthreshold depression. And the damage will be more severe and extensive when the emotional processing is strengthened.