Objective    To explore the application value of combined detection of D-dimer (DD) and fibrinogen (FIB) in the diagnosis of deep venous thrombosis (DVT).     Methods       The study included 3 groups: a DVT group

a non-thrombotic disease control group and a normal control group. The DVT group consisted of 50 patients with the mean age of 45.6±5.2 years

who were diagnosed with DVT (28 males and 22 females) and admitted to the vascular surgery department of affiliated hospital of Chengde medical college from January 2013 to September 2014. The non-thrombotic disease control group consisted of 50 patients with the mean age of 47.5±2.3 years

who were documented with nonthrombotic disease (25 males and 25 females) and admitted to the department during the same period

and there were 18 cases of great saphenous varicose veins of lower limb

22 cases of lower extremity atherosclerotic occlusive disease

 5 cases of carotid artery stenosis

2 cases of abdominal aortic aneurysm and 3 cases of aortic dissection. The normal control group consisted of 40 healthy people with the mean age of (46.7±3.9) years old

who were checkedup in our hospital (19 males and 21 females). The serum concentrations of DD and FIB were tested.    Results         The serum concentrations of DD and FIB were 0.91±0.26 and 5.18±0.09 g/L in the DVT group

0.54±0.06 and 4.57±0.69 g/L in the nonthrombotic disease control group

and 0.29±0.09 and 2.71±0.29 g/L in the normal control group

respectively. The levels of DD and FIB in the DVT group were significantly higher than those of the other groups (P0.05). The diagnostic sensitivity

specificity

positive predictive value and negative predictive value of DD for DVT were 90.00%

74.44%

65.67% and 91.78%

respectively. The corresponding values of FIB for DVT were 74.00%

76.67%

63.79% and 84.15%

respectively. Furthermore

the corresponding values of combined detection of DD and FIB for DVT were 92.00%

7333%

65.71% and 94.29%

respectively.     Conclusion       Combined detection of serum DD and FIB levels has an important clinical value. It can improve the positive detection rate and decrease the missed diagnosis in the early diagnosis of DVT.