Objective      To study the effect of evodiamine (EVO) on glucose metabolism of brain and interscapular brown adipose tissue (IBAT) in mice quantified by 18F-fluoro-deoxyglucose (

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F-FDG) positron emission tomography (PET)/computed tomography (CT) scanning.       Methods      Kunming mice were randomized into 5 groups (each group n=3) and intraperitoneal (i.p.) injected with EVO doses of 0

125

250

375 and 500 mg/kg

and

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F-FDG was given in 30 min later. The upta

ke of

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F-FDG in the brain and IBAT were observed after 1 h and standard uptake value (SUV) were measured by micro-PET/CT.       Results      The SUVs of IBAT were 0.81±0.08

0.53±0.06

1.30±0.17

1.70±0.10 and 0.74±0.21 corresponding to EVO doses of 0

125

250

375 and 500 mg/kg. Compared to the control

the increased SUVs in the groups of 250 and 375 mg/kg were significant (P0.05). The SUVs of brain were 1.43±0.15

2.20±0.20

2.80±0.20

3.33±0.15 and 4.00±0.25

in a dose-dependent manner. Difference between each 2 groups was statistically significant (P0.05).       Conclusion      EVO enhances glucose metabolism in mice IBAT and brain.