Objective      To induce and evaluate the onsets and features of relapsing experimental autoimmune uveoretinitis (EAU) in B10.RⅢ mice.       Methods      B10.RⅢ mice of the experimental group were immunized with interphotoreceptor retinoid-binding protein (IRBP) 161-180 peptides in complete Freund’s adjuvant (CFA)

while the mice of the control group were immunized with CFA-PBS. The clinical findings and histopathologic changes of both groups were observed at weekly intervals for 5 weeks after primary immunization. At the resolution of inflammation

the mice underwent secondary immunization with IRBP-CFA or CFA-PBS to evaluate the inflammation relapse.       Results      The primary inflammation signs were observed on the 7th day

rose to the peak on the 14th day

followed by gradual regression

and disappeared on the 35th day after primary immunization. The mice underwent secondary immunization on the 35th day after primary immunization. The relapsing inflammation signs were observed on the 36th day

and then rose to the climax on the 42nd day. The inflammation was alleviated on the 50th day

but about 1/5 of the mice still maintained inflammation signs on the 96th day after primary immunization. The main clinical findings in the mice were ciliary injection

corneal opacity

fibrinous exudates in the anterior chamber

and lesions of the pupil. The prominent histopathologic lesions included inflammatory cellular infiltration in the retina and choroid

retinal vasculitis and granuloma

disorganization and loss of photoreceptors

and subretinal exudates.       Conclusion      The relapsing EAU mouse model is characterized with chronic course and clinical and histopathologic findings similar to human uveitis

so it can be used as a suitable model for research of human uveitis.