Objective      To investigate the correlation of the polymorphism of X-ray repair cross complementing group 1 (XRCC1) Arg399Gln with acute radiotherapy-induced injuries in cervical cancer.       Methods      A total of 152 patients with pathology-confirmed cervical cancer admitted in our hospital from July 2011 to June 2015 were recruited in this study. Single nucleotide polymorphisms (SNPS) in XRCC1 gene were analyzed by Sanger sequencing

and the results were evaluated with the occurrences of acute radiotherapy-induced cystitis and proctitis in the patients.       Results      In the cohort

there were 78

56 and 18 patients respectively carrying XRCC1 Arg/Arg

Arg/Gln

and Gln/Gln

and 47 cases of grade 2-3 acute cystitis

100 of grade 2-3 acute proctitis and none of grade 4 cystitis and proctitis. After adjustment for other clinical factors

multivariate logistic regression analysis indicated that the patients carrying XRCC1 399Arg/Gln and 399Gln/Gln had higher risk for the development of grade 2-3 cystitis when compared with those carrying wide type (OR=4.114

95%CI: 1.746～9.693; OR=9.096; 95%CI: 2.707～30.566)

and were prone to having of grade 2-3 proctitis (OR=5.011

95%CI: 2.169～11.575; OR=7.165; 95%CI: 1.506～34.092).       Conclusion      SNPs of XRCC1 codon 399 is related with acute radiotherapy-injured cystitis and proctitis in cervical cancer

and of potential predictive value for side effects of radiotherapy.