With the aging of society and the development of medically diagnostic techniques

the incidence and diagnosis rate of Alzheimer’s disease (AD) have been increasing. However

there is no breakthrough in the treatment of AD at present. Thus

it is necessary to explore the optimal management for AD patients under the current condition. AD is characterized by multi-target mechanisms of pathogenesis and complexity of clinical symptoms

which requires more comprehensive treatment and management. Here

we elaborate of A2G plus (one or more of A to G and other plus measures) comprehensive management model for AD patients. This model is built upon 4 international authoritative guidelines

multi-target mechanisms of disease

existing therapeutic drugs and methods

and long-term clinical experiences and patient’s individual condition

and provides comprehensive treatment and management for AD patients.