Objective      To investigate the value of serum soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) in the prognosis of patients with severe sepsis.       Methods      Eight-three patients with severe sepsis were involved in the retrospective study. They were divided into survivor group (n=63) and non-survivor group (n=20) according to 28-day mortality. Baseline indexes

APACHEⅡ peak score

serum concentrations of sTREM-1 and procalcitonin (PCT)

and whole blood levels of C-reactive protein (CRP) and lactate (Lac) were recorded within 24 h after admission

and the differences of above indicators were analyzed. The above indicators in the prognosis was tested by receiver operator characteristic (ROC) curve. Multivariate logistic regression analysis was performed to evaluate the risk factors.       Results      There was no significant differences in the baseline indexes between the 2 groups (P0.05). The serum concentration of sTREM-1 and APACHEⅡ peak score in the survivors were significantly higher than those in the non-survivors (P0.05). But no significant differences were observed in the serum PCT and blood CRP and Lac (P0.05). The area under ROC curve of serum concentration of sTREM-1 was 0.770. Multivariate logistic regression analysis showed that APACHEⅡ score and serum concentration of sTREM-1 were independent risk factors for the prognosis of severe sepsis.       Conclusion      The serum concentration of sTREM-1 might be a reliable indicator and independent risk factor for the prognosis of patients with severe sepsis.