Objective      To investigate the clinical and pathological characteristics of diabetic nephropathy (DN) patients with edema or not.        Methods      Totally 170 patients with type 2 diabetic nephropathy

which were diagnosed by renal biopsy

were divided into groups: edema DN(E-DN) and nonedema DN (NE-DN) group. The clinical and pathological features and prognosis were compared between the 2 groups.        Results      Compared with the baseline values

the renal pathological changes were more serious in group E-DN. The integral of the renal interstitial lesions was significantly larger than that of the NE-DN group（P0.05）. And glycosylated hemoglobin (HbA1c)

blood pressure(BP)，total cholesterol (TC)

percentage of 24 h urinary protein leakage over 3.5 g were significantly higher than those in group NE-DN（P0.05

P0.01）. E-DN group of eGFR and plasma albumin (ALB) were significantly lower than the NE-DN group. In the 2 years’ follow-up

E-DN group of patients had eGFR decreased significantly greater than the NE-DN group（P0.05

P0.01）.The incidence of renal end events was also significantly higher than that of the latter（P0.05）. Survival analysis showed that the prognosis of group E-DN was poor （Chi square=17.460，P0.01）. Risk factor analysis showed that ALB(RR=0.938

P=0.004)

eGFR (RR=0.985

P0.01)

interstitial lesion of the kidney (RR=1.236

P=0.012)

TC (RR=1.192

P=0.015)

and edema (RR=6.412

P0.01) were independent risk factors of death in DN kidney.       Conclusion      When compared with NE-DN group

the E-DN group has a poor blood glucose control

low serum albumin

lipid metabolism disorder

and renal interstitial lesions

and the renal median survival time is short. Edema was an independent risk factor for renal death.