Objective      To investigate the correlation between serum gastrin level and coronary heart disease (CHD).       Methods      A case-control method was used in this research. Eighty-three patients were selected as the CHD group according to the results of coronary angiography in our department from January 2013 to December 2014. The CHD group was divided into single-branch lesion group

double-branch lesion group and triple-branch lesion group according to the results of coronary angiography. The lesion severity of CHD was calculated with Gensini scores. Participants of the control gro

up had no CHD and other diseases of important organs. The age

gender and digestive tract disease of the control group were matched with those of the CHD group. Enzyme-linked immunosorbent assay was used to measure the levels of fasting serum gastrin (FG) and postprandial 1 h serum gastrin (PG1h).       Results      PG1h and PG1h/FG in the CHD group significantly increased compared with the control group (P0.01). It showed that PG1h/FG was a risk factor of CHD after controlling the confounding factors of CHD with Logistic regression model. PG1h/FG was positively correlated with the lesion severity of CHD in the CHD group (r

2

=0.453).       Conclusion      The increase of serum gastrin level is not only correlated with CHD

but also positively correlated with the lesion severity of CHD.