Objective      To compare the safety

efficacy and

incidence of severe complications of transurethral ventral preserving enucleation of the prostate (TUVPEP) with transurethral resection of the prostate (TURP).       Methods      Two hundred patients with benign prostatic hyperplasia (BPH) admitted in our institute from April 2010 to April 2015 were prospectively recruited in this study. According to the size of the prostate

they were divided into M (the prostate in weight of 45～80 g) and L (80 g ) groups. Every group was further randomly divided into 2 subgroups to respectively undergoing TUVPEP (M1 and L1) or TURP (M2 and L2). Our patent Zhang’s multifunctional resectoscope was employed in TUVPEP (also named as Zhang’s enucleation of the prostate). The operative time

intra-operative bleeding volume

and post-operative hospital stay were recorded. International prostate sympathetic score (IPSS)

score of quality of life (QOL)

maximum flow rate (Q

max

)

urethral functional length (UFL)

urethral functional area (UFA) and incidences of severe complications were investigated in 6 month after operation

and the results were compared between the 2 operative approaches.       Results      A total of 179 patients completed the 6-month postoperative follow-up. Blood loss was lesser in those receiving TUVPEP than TURP during the operation (M: 27.63±20.35 vs 31.82±17.35 mL

P0.05; L: 58.35±49.79 vs 73.39±43.78 mL

P0.05)

and the durations of postoperative hospitalization was also short in the first approach than the latter (M: 3.80±1.03 d vs 6.61±1.91 d

P0.01; L: 4.06±1.29 d vs 5.94±1.84 d

P0.001). Postoperative Q

max

was obviously high in the former than the latter (M: 21.10±7.56 vs 16.10±5.94 mL/s

P0.01; L: 25.70±9.18 vs 16.20±5.01 mL/s

P0.01). The incidences of severe complications were lower in the former than the latter approaches (10% vs 21%)

and so was the re-operative rate (0% vs 6%).       Conclusion       Compared to TURP

our Zhang’s enucleation of the prostate has significantly smaller blood loss and shorter operation time

obviou

sly improves Q

max

and reduces the incidence of severe complications

decreases the re-operative rate

and shortens the times of indwelling catheter and hospital stay.