Objective      To investigate the influence of N-acetylcysteine(NAC) in the treatment of combined pulmonary fibrosis and emphysema syndrome index of oxidative stress and pulmonary function.       Methods      Atotal of 112 case of CPFE syndrome admitted in our hospital from January 2013 to December 2014 were randomly divided into 2 groups: the treatment group and the control group

56 cases in each. Two groups were given conventional anti-inflammatory

bronchodilator and oxygen therapies and other basic therapy

and the treatment group received oral NAC treatment in addition. The contents of malondialdialdehyde (MDA) glutathione peroxidase superoxide dismutase (GSH-Px) and (SOD) of 2 groups of patients before and after treatment were detected by chemical colorimetry

and forced expiratory volume 1 second (FEV1)

forced vital capacity (FVC)

single breath diffusing capacity for carbon monoxide(DLCOSB) before and after treatment their were compared.       Results      The levels of MDA in blood plasma of the treatment group Significantly lower than the control group after treatment

SOD and GSH-Px levels were significantly higher

the improvement of FEV1

FVC and DLCOSB in treatment group was better than that in control group.       Conclusion      N-acetylcysteine treatment of CPFE syndrome patients can not only exert antioxidant effect

but also can improve the pulmonary function of patients

especially the pulmonary dispersion function.