Objective        To determine the effect of intervention measures to improve treatment compliance in the patients with tuberculosis.       Methods        Eight hundreds and forty-six patients with tuberculosis were subjected by cluster random sampling from the patients who registered in 88 Disease Control and Prevention Centers in Guizhou Province from November 4

2013 to May 3

2014. They were randomly divided into the intervention group and control group. After 2 months of standard treatment

the patients in the control group were treated with routine supervision management

and those in the intervention group were treated with supervision management and intervention measures. The review and medicine delay conditions of patients in the late of May and June (August for retreatment) were analyzed.       Results        Of the 846 patients

besides 54 cases who quitted from the study because of death or refusal

792 cases were observed for the review and medicine in late May and June (August). There was no significant difference between the basic condition of the control group and intervention group (P0.05). The treatment compliance was significantly higher in the intervention group than the control group (P0.05). Multivariate logistic regression analysis showed that the diagnosis results of the late May indicated that the compliance of smear-positive patients were better than those negative (OR=1.51

P0.05)

and were better in the intervention patients than those without (OR=1.83

P0.05)

and the results of the late August

the compliance better in Han nationality than minority nationalities (OR=1.63

P0.05)

and similar results were seem in the smear-positive patients and negative ones (OR=1.59

P0.05)

and those receiving intervention or not (OR=2.03

P0.05). There were delays in the patients in both groups

and the average delay days was significant lower in the intervention group than the control (P0.05).       Conclusion      Intervention based on the development situation in Guizhou Province can significantly improve the treatment compliance and shorten the delay review time in the tuberculosis patients. This intervention does not need a lot of investment and is suitable for promotion in Guizhou Province.