Objective      To investigate the brain neutral mechanism of emotional disturbance induced by sleep deprivation.       Methods      Resting-state functional magnetic resonance imaging (fMRI) was used to compare the whole brain functional connectivity patterns of 14 male young healthy voluen teers in the rested wakefulness state and sleep deprivation state.       Results      Sleep deprivation resulted in a significant decrease in the functional connectivity between the sub regions of amygdala and several regions including the dorsolateral prefrontal cortex

dorsal anterior cingulate cortex

dorsal posterior cingulate cortex and inferior frontal gyrus (P0.05). The functional connectivity was significantly increased between the sub regions of amygdala and several regions including the posterior cingulate cortex/presumes

medial prefrontal cortex

rostral anterior cingulate cortex and parahippocampal gyrus. Furthermore

the  total score of profile of mood states (POMS) was significantly higher in the sleep deprivation state than in the rested wakefulness state. The functional connectivity between the superficial amygdala and medial prefrontal cortex was significantly correlated with the POMS total score (r=0.415，P0.05).       Conclusion      Different sub regions of amygdala have distinct functional connectivity patterns. After sleep deprivation

the functional connectivity between the amygdala and regions of default mode network is increased while that between the amygdala and regions of executive control network is decreased. These alterations may be the essential neural mechanism of emotion regulation decline induced by sleep deprivation.