Objective      To investigate the feasibility and advantages of daily hemodialysis (DHD) by comparing the application of DHD and conventional hemodialysis (CHD) in induction period.       Methods      Forty-four patients beginning to accept hemodialysis due to chronic renal failure in our center from 2013 to 2014 were prospectively enrolled in this study

and then randomly divided DHD group (n=22) and CHD group (n=22). Urea nitrogen (BUN)

serum creatinine (Scr)

hemoglobin (Hb)

mean arterial pressure (MAP)

heart rate (HR)

and APACHEⅡ score were determined on 1 d before and on the 7th day after hemodialysis. Headache score

nausea score

somnipathy score

dysphoria score

somatization score and total score (symptom check list-90

SCL-90) were also studied.       Results      On admission

there were no statistical differences in BUN

Cr

Hb

MAP

HR and APACHEⅡ score between the 2 groups (P0.05). On the 7th day after the treatment

Scr (465.44±117.70 vs 594.60±157.38)

MAP (99.71±12.23 vs 109.54±12.14) and APACHEⅡ score (13.71±2.13 vs 15.38±1.94) were statistically lower in the DHD group than the CHD group (all P0.05). And the former group had obviously lower headache score (1.00 vs 2.00)

nausea score (1.00 vs 2.00)

somnipathy score (1.53±0.43 vs 1.92±0.61)

dysphoria score (1.28±0.34 vs 1.53±0.37)

somatization score (1.50±0.46 vs 1.90±0.58) and total score (1.38±0.38 vs 1.68±0.40) than the latter one (all P0.05).       Conclusion      DHD

instead of CHD

is a safe

stable

high efficient and comfortable blood purification process in induction period.