Sepsis is a life-threatening disease for infected patients and there are few effective remedies for sepsis. Almost all the therapeutic strategies based on anti-inflammation or anti-coagulation have been failed since sepsis is a complicated inflammatory response that involves immune

coagulation and neuroendocrine systems

and thus the treatments directed against only one of the systems are not able to produce beneficial effects.Pattern recognition theory which means the pathogen-associated molecular patterns trigger sepsis by being recognized by pattern recognition receptors

elucidates the mechanism of sepsis

therefore we present a strategy on the management of sepsis at the source by targeting the major bacterial pathogen-associated molecular patterns. According to the current studies

the strategy is feasible thus providing a promising way to treat sepsis.