Objective      To evaluate the curative effect of sodium bicarbonate on huge bezoars with endoscopic mechanical lithotripsy.       Methods      Sixty-eight patients with huge bezoars were detected with a gastroscope in our hospital from December 2009 to July 2014

and they orally took 5% sodium bicarbonate 125 mL for 4 times per day. According to sodium bicarbonate taking time

the patients were randomly divided into drug-free group

3-day group

5-day group

and 7-day group. The bezoars were broken into pieces and removed out after gastroscopy. If the bezoars were not removed out at a time

5％ sodium bicarbonate was administrated again in the same way. After that

the bezoars were broken into pieces and removed out until all the bezoars were removed out.       Results      The huge bezoar removal rates of the 4 groups were 23.5%

47.1%

64.7%

and 94.1%

respectively

on the first time

were 41.2%

35.3%

29.4%

and 5.9%

respectively

on the second time

and were 35.3%

17.6%

5.9%

and 0

respectively

on the third time. There was no patient with bleeding

gastrointestinal perforation and intestinal obstruction.       Conclusion      Sodium bicarbonate combined with gastroscopy is safe and effective in removing huge bezoars and is worth of clinical application. Especially

after taking sodium bicarbonate for 7 d

one-time success rate and efficiency are improved.