Objective      To investigate the influence of CD36 in hematoma absorption and neurologic deficit scores (NDS) in the patients with intracerebral hemorrhage (ICH).        Methods      A total of 349 ICH patients treated in our department from July 2012 to June 2014 were selected as the research objects. Among them

24 ICH patients with cerebral basilar hemorrhage were selected from 35 patients with CD36 mutation

and divided into CD36-deficiency group. Meanwhile

24 CD36-normal ICH patients who had similar features with the CD36-deficency group were selected as the CD36-normal group. The hematoma absorption

inflammatory responses and NDS of the 2 groups were compared.       Results      Thirty-five patients (10.03%) with CD36 deficiency were screened from the 349 ICH patients. There were no significant differences in the age

gender

hematoma volume on admission

risk factors

and other baseline data between the 2 groups (P0.05). On day 7 after ICH

the hematoma absorption of CD36-deficiency patients was significantly lower than that of CD36-normal patients (22.4%±2.4% vs 44.8%±5.1%

P0.05)

as well as the reduction rate of pro-inflammatory factors on day 14 after ICH (P0.05). Moreover

on the days 14

30 and 90 after ICH

the NDS of CD36-deficiency patients were higher than those of CD36-normal patients (P0.05).       Conclusion      CD36 may play an important role in promoting the hematoma absorption and improving the NDS after ICH.