Objective      To compare the pharmacokinetic behaviors of demethoxycurcumin nanoemulsion and free demethoxycurcumin suspension in rats

and estimate the pharmacokinetic characteristics of demethoxycurcumin nanoemulsion.       Methods      Blood was collected from retinal venous plexus of SD rats after intra-gastrical administration of demethoxycurcumin nanoemulsion or free demethoxycurcumin suspension

and the demethoxycurcumin concentration in blood plasma was determined by HPLC.       Results      The pharmacokinetic parameters of demethoxycurcumin nanoemulsion and free demet

hoxycurcumin were calculated as follows: AUC

(0-∞)

(962.84±75.27) vs (235.62±11.28)μg·h/L

T

1/2

(38.85±6.54)  vs (8.23±2.92) h

and MRT

(0-∞)

(50.92±4.58) vs (8.46±2.61) h. The AUC

(0-∞)

T

1/2

and MRT

(0-∞)

of demethoxycurcumin nanoemulsion were 4.08 times

4.72 times and 6.01 times higher than those of free demethoxycurcumin

respectively.       Conclusion      Compared with free demethoxycurcumin suspension

demethoxycurcumin nanoemulsion has higher bioavailability.