Objective      To analyze the correlation of the parameters derived from dynamic contrast enhanced magnetic resonance imaging (DCE

-MRI)

Ktrans (volume transfer constant) and Ve (volume fraction of extravascular extracellular space)

and those from dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI)

rCBV (relative cerebral blood volume) and rCBF (relative cerebral blood flow) with the grades of glioma

and compare the values of the parameters in the grading.       Methods      A total of 85 patients with different types of pathologically confirmed gliomas

including 39 with low grade gliomas (LGGs) and 46 with high grade gliomas (HGGs)

firstly diagnosed in our hospital from September 2013 to September 2014 were enrolled in this study. DSC MRI and/or DCE-MRI were performed on the patients before surgery

and the corresponding perfusion parameters were obtained after software processing. Analysis of variance (ANOVA) was used to compare the maximal values of Ktrans

Ve

rCBV and rCBF among those gliomas of different grades. Pearson correlation analyses were used to determine correlation of Ktrans

Ve

rCBV

and rCBF with glioma grades. Receiver operating characteristic (ROC) curve analyses were carried out to determine the threshold for Ktrans

Ve

rCBV and rCBF to distinguish different grades of gliomas.       Results      The mean values of Ktrans and Ve were significantly higher in HGG than LGG (0.118±0.062 vs 0.029±0.020/min

-1

0.601±0.246 vs 0.157±0.177

both P0.001). When the threshold value of Ktrans was 0.055/min

-1

the sensitivity and specificity were 89.7% and 90.5%

respectively. And when the value of Ve was 0.343

the sensitivity and specificity were 86.2% and 85.7%

respectively. The mean values of rCBV and rCBF were significantly higher in HGG (2.649±1.351 and 2.427±1.248

respectively) than LGG (1.480±0.391 and 1.377±0.545

both P0.001). The threshold values of rCBV (2.043) and rCBF (1.886) provided the sensitivity (95.2% and 85.7%) and specificity (92.9% and 85.7%) in differentiation between LGG and HGG.       Conclusion      The parameters of Ktrans and Ve

and those of rCBV and rCBF a

re closely correlated with histopathological grades of gliomas. rCBV has the highest sensitivity and specificity

followed by Ktrans

Ve and rCBF in order.