Objective      To compare the effect of different sedative plans on electrocorticography (EcoG) in patients with intracranial tumors

who were undergoing surgery for epilepsy

and discuss the selection of sedative plan suitable for epilepsy surgery.       Methods      One hundred of patients with secondary epilepsy caused by intracranial tumors from September 2012 to January 2014 were randomly divided into 4 groups (25 patients in each group). Group A underwent anesthesia induction by intravenous injection of propofol (2 mg/kg)

sufentanil (0.5 μg/kg) and rocuronium (0.6 mg/kg)

and anesthesia maintaining by inhalation of 1% sevoflurane while controlling the concentration at 0.80±0.20 times of minimal alveolar concentration (MAC)

intravenous pumping of propofol 1.60-2.50 mg/(kg·h) and remifentanil 1 μg/(kg·h)

and intermittent application of rocuronium. Propofol was stopped about 10 min before the first ECoG monitoring (monitoring 1)

and the sevoflurane concentration was controlled at MAC0.5 during monitoring. Group B underwent the same treatment as group A except that intravenous injection of midazolam (0.1 mg/kg) was used for inducing anesthesia. Group C underwent the same treatment as group A except that propofol pumping was not stopped before monitoring. Group D underwent the same treatment as group A except that the concentration of sevoflurane was controlled at 0.5-1.0 times of MAC during monitoring. The second ECoG monitoring (monitoring 2) was performed after lesion resection

and the number of burst suppression (BS) in each group was statistically analyzed.       Results      The number of BS in group A was significantly less than that in group B

and the difference was statistically significant (P0.05). There was no statistically significant difference in the number of BS between group A and group C (P0.05). The number of BS in group A was significantly less than that in group D

and the difference was statistically significant (P0.05). There was one case with BS during monitoring 2 in group B. There were 13 patients undergoing intraoperative waken-up in this study

and when propofol was intravenously injected

12 patients (92.31%) showed BS.       Conclusion      When the patients with secondary epilepsy caused by intracranial tumors undergo surgery

the suggested sedative plan is to choose intravenous injection of propofol (2 mg/kg) for inducing anesthesia

and 1% sevoflurane inhalation and propofol pumping [1.60-2.50 mg/(kg·h)] for maintaining anesthesia. Propofol should be stopped at 10-15 min before ECoG monitoring

and the concentration of sevoflurane is lower than 0.5 times of MAC during monitoring

in order to reduce the anesthetic impact on ECoG.