芒果苷联合卸负荷改善压力超负荷大鼠心室肥厚

邹书帆; 焦蔡领; 蹇朝; 肖颖彬; 唐富琴; 陈林

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芒果苷联合卸负荷改善压力超负荷大鼠心室肥厚

论著 | 更新时间：2026-01-09

- 芒果苷联合卸负荷改善压力超负荷大鼠心室肥厚
- Reversal effect of mangiferin combined with pressure unloading on left ventricular hypertrophy in rats
- 陆军军医大学学报 2015年37卷第6期页码：527-531
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  中图分类号： R542.205;R965;R972.9
- 纸质出版：2015
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邹书帆,焦蔡领,蹇朝,肖颖彬,唐富琴,陈林.芒果苷联合卸负荷改善压力超负荷大鼠心室肥厚[J].陆军军医大学学报(原第三军医大学学报),2015,37(06):527-531.

　Zou Shufan,Jiao Cailing,Jian Zhao,Xiao Yingbin,Tang Fuqin,Chen Lin.Reversal effect of mangiferin combined with pressure unloading on left ventricular hypertrophy in rats[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(06):527-531.
邹书帆,焦蔡领,蹇朝,肖颖彬,唐富琴,陈林.芒果苷联合卸负荷改善压力超负荷大鼠心室肥厚[J].陆军军医大学学报(原第三军医大学学报),2015,37(06):527-531. DOI：

　Zou Shufan,Jiao Cailing,Jian Zhao,Xiao Yingbin,Tang Fuqin,Chen Lin.Reversal effect of mangiferin combined with pressure unloading on left ventricular hypertrophy in rats[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(06):527-531. DOI：

摘要

目的通过卸负荷及药物干预相结合建立大鼠胸骨上小切口缩窄及松解模型，探讨芒果苷对大鼠压力超负荷后卸负荷的心室肥厚转归的影响。方法选用5周龄、体质量150～180 g雄性SD大鼠48只，行非人工通气下胸骨上小切口升主动脉缩窄术致大鼠左心室肥厚，利用单一去缩窄以及去缩窄联合应用芒果苷干预方法，将所有存活动物随机分为假手术组、超负荷组（升主动脉缩窄6周）、卸负荷组（升主动脉缩窄术后6周后松解4周）以及芒果苷组[缩窄术后6周后松解，松解术后以芒果苷干预4周，20 mg/（kg·d）.i.g]，通过心肌大体标本、动物超声心动图，病理学染色比较大鼠在此过程中的心脏形态、质量，左室壁厚度及心肌病理学改变。结果与假手术组相比，超负荷组心肌左室后壁收缩期厚度（4.25±0.43）mm、舒张期厚度（2.89±0.42）mm及室间隔收缩期厚度（3.92±0.71）mm、舒张期厚度（2.59±0.49）mm显著增厚（P0.01），心脏体积增大、心脏质量体质量比（4.44±0.77）mg/g明显升高（P0.01）、心肌细胞排列紊乱，胞质增多，间质纤维化明显。卸负荷后左室后壁收缩期厚度（3.85±0.56）mm、舒张期厚度（2.47±0.52）mm及室间隔收缩期厚度（3.81±0.53）mm、舒张期厚度（2.51±0.54）mm有一定程度的改善，但不明显。心脏体积减小、心脏质量体质量比(3.03±0.18）mg/g降低（P0.01）、心肌细胞体积缩小但排列紊乱，间质纤维化程度无明显减轻。芒果苷联合卸负荷干预后较单一卸负荷组左室后壁收缩期厚度（2.80±0.37）mm、舒张期厚度（1.94±0.27）mm，室间隔收缩期厚度（2.90±0.51）mm、舒张期厚度（1.89±0.38）mm及心脏质量体质量比（2.32±0.33）mg/g改善明显（P0.01），心脏体积进一步减小，心肌细胞体积缩小且排列规则，间质纤维化程度有一定改善。结论芒果苷联合卸负荷可显著改善超负荷大鼠心室肥厚。

Abstract

Objective To investigate the reversal effect of mangiferin combined with pressure unloading on left ventricular hypertrophy (LVH) through the pressure overload-unload model of rats. Methods The pressure overload-induced LVH rat model was established by aortic coarctation. All surviving rats were randomly divided into a sham group

an overload group (ascending aorta coarctation for 6 weeks)

an unload group (release of aorta coarctation for 4 weeks) and a mangiferin group (aorta coarctation release combined with 20 mg/(kg·d）

i.g. mangiferin gavage for 4 weeks 3. The myocardial gross specimen

animal echocardiography and myocardial pathological staining were used to observe the heart appearance

heart mass

left ventricular thickness and myocardial pathological changes. Results Compared with the sham group

the left ventricular posterior wall thickness in systole (LVPWs

4.25±0.43 mm)

left ventricular posterior wall thickness in distole (LVPWd

2.89±0.42 mm)

interventricular septal thickness in systole (IVSs

3.92±0.71 mm)

interventricular septal thickness in diastole (IVSd

2.59±0.49 mm)

heart size

heart weight

and heart weight/body weight (HW/BW

4.44±0.77 mg/g) were increased obviously in the overload group (P0.01)

and meanwhile

myocyte disarray

increased cytoplasm

and interstitial fibrosis appeared in pathological staining. In the unload group

LVPWs (3.85±0.56 mm)

LVPWd (2.47±0.52 mm)

IVSs (3.81±0.53 mm)

and IVSd (2.51±0.54 mm) were improved to a certain extent

and the heart size

heart weight and HW/BW (3.03±0.18 mg/g) decreased (P0.01) compared with overload group. Pathological staining of the unload group demonstrated that myocardial cells were shrunk and disorganized

and interstitial fibrosis was not significantly alleviated. In the mangiferin group

the LVPWs (2.80±0.37 mm)

LVPWd (1.94±0.27 mm)

IVSs (2.90±0.51 mm)

IVSd (1.89±0.38 mm)

HW/BW (2.32±0.33 mg/g) further decreased compared with the unload group (P0.01)

and pathology staining showed that myocardial cells showed obvious shrinkage and regular arrangement

and interstitial fibrosis was slightly alleviated. Conclusions Mangiferin combined with pressure unloading has significant reversal effect on the pressure overload-induced LVH rats.

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