西吡氯铵含片对口臭致臭菌和致臭底物作用的实验研究

张波; 李丽; 张迪; 刘长虹; 段培佳; 钟惠兰

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西吡氯铵含片对口臭致臭菌和致臭底物作用的实验研究

论著 | 更新时间：2026-01-09

- 西吡氯铵含片对口臭致臭菌和致臭底物作用的实验研究
- Effects of cetylpyridinium chloride buccal tablets on halitosis-correlated bacteria and substrate
- 陆军军医大学学报 2014年36卷第16期页码：1750-1753
- 作者机构：
- 作者简介：
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- DOI：
  中图分类号： R781.9;R965;R978.2
- 纸质出版：2014
- 稿件说明：
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张波,李丽,张迪,刘长虹,段培佳,钟惠兰.西吡氯铵含片对口臭致臭菌和致臭底物作用的实验研究[J].陆军军医大学学报(原第三军医大学学报),2014,36(16):1750-1753.

　Zhang B,Li Li,Zhang Di,Liu Changhong,Duan Peijia,Zhong Huilan.Effects of cetylpyridinium chloride buccal tablets on halitosis-correlated bacteria and substrate[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(16):1750-1753.
张波,李丽,张迪,刘长虹,段培佳,钟惠兰.西吡氯铵含片对口臭致臭菌和致臭底物作用的实验研究[J].陆军军医大学学报(原第三军医大学学报),2014,36(16):1750-1753. DOI：

　Zhang B,Li Li,Zhang Di,Liu Changhong,Duan Peijia,Zhong Huilan.Effects of cetylpyridinium chloride buccal tablets on halitosis-correlated bacteria and substrate[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(16):1750-1753. DOI：

摘要

目的通过西吡氯铵含片对口源性口臭致臭菌和致臭底物的实验研究，探讨西吡氯铵含片对口源性口臭治疗的效果。方法通过连续稀释法检测西吡氯铵对致臭菌牙龈卟啉单胞菌(

P.gingivalis

)、中间普雷沃菌(

P.intermedius

)、具核梭杆菌(

F.subsp nucleatum

)和口腔正常有益菌唾液链球菌(

Streptococcus salivarius

)的最低抑菌浓度(minimal Inhibitory Concentration

MIC)；并检测西吡氯铵对3种致臭菌分别培养4 h和8 h后的挥发性硫化物(volatile sulfur compounds

VSCs)水平的影响；进一步通过半胱氨酸激发模拟口臭实验，检测西吡氯铵含片对激发的VSCs的抑制率和持续时间。结果西吡氯铵对所有实验菌具有抑菌能力，但对唾液链球菌MIC值均高于其对致臭菌的MIC值；1%西吡氯铵与1%氯己定在作用Pg、Pi和Fn 4 h时，抑制作用相当（

0.05)，但在作用8 h时，抑制作用西吡氯铵低于氯己定(

0.05)；半胱氨酸激发模拟口臭实验结果显示，西吡氯铵含片在30～120 min内对VSCs水平的抑制率与1%聚维酮碘漱口液相当(

0.05)，在60～120 min内高于西吡氯铵漱口液(

0.05)。且西吡氯铵含片下调半胱氨酸激发的VSCs水平的持续时间为235 min，长于西吡氯铵漱口液，差异有统计学意义(

0.05)。结论西吡氯铵含片能有效抑制口腔致臭菌，对治疗口源性口臭有良好的效果。

Abstract

Objective To evaluate the effects of cetylpyridinium chloride buccal tablets on halitosis-correlated bacteria and substrate. Methods Three halitosis-correlated bacteria

Porphyromonas gingivalis

(

)

Prevotella intermedia

(

)

and

Fusobacterium nucleatum

(

) and a normal bacterium

Streptococcus salivarius

(

) were chosen as the experimental bacteria. The minimal inhibitory concentration (MIC) was tested with serial dilution test. The volatile sulfur compounds (VSCs) were detected with Halimeter in 4 and 8 h after cetylpyridinium chloride buccal tablet treatment of the 3 anaerobic bacteria. The effects of cetylpyridinium chloride on the odor production of mouth-borne halitosis-correlated bacteria

in vivo

were assessed with cysteine challenge test

and the effectiveness was determined by the percentage of the VSCs response and effect duration. Results The data of the serial dilution test showed that cetylpyridinium chloride had antimicrobial activity

and the MIC against

was higher than those against the three halitosis-correlated bacteria. Cetylpyridinium chloride (1%) significantly inhibited the production of VSCs in

and

and its efficacy was equivalent with 1% after 4 h treatment (

0.05). However

its inhibitory efficacy was lower than after 8 h treatment (

0.05). The cysteine challenge test data showed that the cetylpyridinium chloride buccal tablets significantly lowered the levels of VSCs. And their inhibitory efficacy was equivalent with that of 1% povidone iodine mouthwash within 30 to 120 min (

0.05) and superior to cetylpyridinium chloride mouthwash within 60 to 120 min (

0.05). Moreover

the cetylpyridinium chloride buccal tablets had duration of action of 235 min

also superior to cetylpyridinium chloride mouthwash (

0.05). Conclusion Cetylpyridinium chloride tablets resists halitosis by killing mouth-borne halitosis-correlated bacteria and reducing the levels of VSCs.

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