Objective      To investigate the value of magnifying endoscopy with narrow band imaging (NBI) in the diagnosis of laryngopharyngeal carcinoma.       Methods      A total of 105 000 patients were inspected by magnifying endoscopy in Xinqiao Hospital from July 2011 to June 2014. The pharynx and larynx were observed in both white light and NBI modes during gastroscopy. All lesions were identified pathologically.       Results      The detection rate of laryngopharyngeal tumor was 0.021% (22/105 000)

including advanced squamous cell carcinoma (0.010%

10 cases) and early carcinoma (high grade intraepithelial neoplasia and carcinoma in situ) (0.011%

12 cases). In the diagnosis of advanced stage squamous cell carcinoma

9 cases and 10 cases were detected by NBI endoscopy and white light endoscopy

respectively

and there was no statistically significant difference in the detection rate (P0.05). In the diagnosis of early carcinoma

12 cases and 1 case were found by NBI endoscopy and white light endoscopy

respectively

and the detection rate had statistical significance (P0.01). Laryngopharyngeal carcinoma accompanied by esophageal carcinoma accounted for 45.45% (10/22)

and one case of laryngopharyngeal carcinoma accompanied by rectal carcinoma was found.       Conclusion      The detection rate of early laryngopharyngeal carcinoma by magnifying endoscopy with NBI is higher than that by white light endoscopy

but for the detection rate of advanced laryngopharyngeal carcinoma

NBI endoscopy and white light endoscopy have no difference. Special attention should be paid to the patients with laryngopharyngeal carcinoma accompanied by esophageal carcinoma.