Objective       To study the correlation of Parkinson’s clinical features

such as severity

course

age at onset of Parkinson’s disease (PD)

and L-dopa equivalent daily dose(LEDD) with serological levels of lipids and uric acid.        Methods       Retrospectively analysis of the differences of serologic levels of lipids and uric acid between 130 PD patients and 135 non-PD controls admitted in our department from October 2011 to October 2013 was performed. The difference of the serologic levels of lipids and uric acid among different subclinical types were compared. We also analyzed the correlation between the levels of lipids and uric acid and H-Y stage

course

age at onset and LEDD of PD patients.        Results       Compared with the controls

the serological levels of uric acid

total cholesterol

triglycerides

low-density lipoprotein (LDL) and ApoA1/high-density lipoprotein (HDL) had statistical differences (P0.05). The level of LDL cholesterol had differences between the tremor type and the equivalent type (P0.05). The level of ApoA1/HDL had differences between the rigidity-bradykinesia type and the tremor type (P0.05). Serum ApoA1/HDL was negatively correlated to PD H-Y stage. No more correlation was observed between other serological markers and PD clinic features.        Conclusion       Lower levels of serologic lipids and uric acid may be the risk factors of PD. Lower ApoA1/HDL level links with higher severity of PD. The levels of ApoA1/HDL and LDL in different subclinical types of PD were different. Dopamine replacement therapy doesn’t affect the level of lipid and uric acid.