Objective       To investigate the serum lipid profile

abnormal regional fat distribution

and related factors of lipid metabolism disorders in the patients with Cushing’s syndrome (CS).       Methods       A total of 301 patients suffering from CS admitted in the endocrine department in Chinese PLA General Hospital from December 1992 to May 2012 were subjected in this study. Their serum lipid levels and abnormal distribution of fat were analyzed. The serum lipid profile and abnormal distribution were compared among different types of CS. The related factors of lipid metabolism disorder were analyzed too.       Results       The rate of dyslipidemia in this cohort was 72.43%. The rates of abnormal serum levels of TG

TC

LDL-C and HDL-C (increased and/or decreased) were 40.86%

60.33%

38.14% and 7.44% respectively. Adrenocorticotropic hormone (ACTH)-dependent CS group had longer course

and more obviously central obesity and dyslipidemia than the non-ACTH independent CS group (P0.05)

though there was no statistical difference in serum lipid profile between them (P0.05). Serum levels of TG

TC

LDL-C and HDL-C and abnormal regional fat distribution was positively correlated with serum cortisol level (P0.05)

and LDL-C and urinary free cortisol were independently in positive correlation (P0.05).       Conclusion       The incidence of abnormal lipid metabolism is quite high in the CS patients. The serum level HDL-C is normal or increasing. Urinary free cortisol is the independent factor of LDL-C.