Objective       To determine the therapeutic effects of pulmonary surfactant (PS) combined with high frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) in preterm infants with respiratory distress syndrome (RDS).       Methods        One hundred preterm RDS infants within 12 h after birth admitted in our department from August 2012 to December 2012 were randomly divided into 2 groups

HFOV+PS group (n=48) and CMV+PS group (n=52). Their clinical symptoms and the results of blood gas before and after treatment

mechanical ventilation time

hospitalization time

cure rate and the incidences of complications were compared between the 2 groups.       Results        In HFOV+PS group

both clinical symptoms and blood gas got better (P0.05)

while

hospitalization time and mechanical ventilation time were obviously shorter than CMV+PS group (P0.05). What’s more

cure rate was significant higher in HFOV+PS group than CMV+PS group (P0.05). But the incidences of complications had no statistically significance between the 2 groups (P0.05).       Conclusion        HFOV+PS shows remarkable curative effect in treatment of RDS

and it has important significance in reducing premature mortality and improving cure rate at the same time.