Objective      To compare the clinical characteristics

operation effect and the recovery of patients after operation between cell carcinoma using nephron-sparing surgery (NSS) and radical nephrectomy (RN).       Methods      Clinical data of 463 hospitalized patients with renal cell carcinoma admitted in our hospital from September 2008 to September 2013 were collected and retrospectively analyzed. According to the imaging data and postoperative pathological results in 2010 AJCC kidney cancer standard stage

253 patients of the cohort were defined as unilateral renal cell carcinoma in stage 1

and they were further divided into NSS group (n=99) and RN group (n=154). In the former group

there were 65 males and 34 females with an average age of 56.70±13.59

and 19 with clinical symptoms and 80 without

and 89 cases patients was pathologically identified as clear cell carcinoma. While

the RN group had 154 patients including 98 males and 56 females

at an average age of 57.64±12.39

70 with clinical symptoms and 84 without

and 138 of them was clear cell carcinoma. Clinical data

operation situation

and postoperative condition during follow-up were compared between the 2 groups of patients undergoing different surgical mode.        Results      Early renal cell carcinoma was commonly with no obvious clinical symptoms

and usually firstly diagnosed by B-ultrasound imaging during the period of hospitalization or physical examination. In this cohort

the patients suffering from renal cell carcinoma firstly diagnosed by B ultrasonography accounted for 76.28%. There was no significant difference between the NSS group and RN group in the aspects of age

affected side of tumor

pathological results

recurrence

metastasis and disease-free survival rate at 3 years

and serum levels of creatinine preoperatively and 3 and 12 months postoperatively (P0.05). But significant differences were found in the clinical symptoms

serum creatinine in 24 h postoperatively

bleeding volume during operation

and operation time between the 2 groups (P0.05). RN group had more patients with clinical symptoms (19 vs 70

19.2% vs 45.5%). The NSS group had larger amount of intraoperative bleeding than the RN group (136.87 vs 100.26 mL)

longer operation time (119.17 vs 108.57 min)

but slightly renal damage. The local recurrence (4 vs 8 cases) and distant metastasis (4 vs 9 cases) had no significant difference

nor the disease-free survival rate (96.8% vs 95.9%) between the 2 groups.        Conclusion      B-ultrasonography is helpful to early kidney cancer screening. Evidence indicates that nephron-sparing surgery is better than radical nephrectomy. And the former approach can maximally preserve the nephron and its function

which helps to improve the post-operative quality of life.