In recent years

noninvasive respiratory support in neonates to reduce the risk of tracheal intubation and its complications has become a hotspot of medical research. As a new noninvasive respiratory support mode

nasal intermittent positive pressure ventilation (NIPPV) is mainly applied to neonatal apnea

respiratory support after mechanical ventilation and the initial treatment mode of respiratory support. Compared with nasal continuous positive airway pressure (NCPAP)

NIPPV further reduces the failure rate of extubation after mechanical ventilation and related complications. However

NIPPV has some deficiencies

such as airway pressure instability

the dangers of gastrointestinal flatulence and intracranial hemorrhage. Further basic and clinical researches are needed for the mechanism

indication and long-term effects of NIPPV.