Alzheimer’s disease (AD) is the most common form of dementia in individuals over the age of 65. According to the amyloid-beta (Aβ) cascade hypothesis

Aβ plays a vital role in the development of AD and becomes a major therapeutic target. Tau-targeting therapy

mitochondria-targeting therapy and stem cell transplantation are also known intervention strategies. Because multifactors are involved in the disease pathogenesis and the pathogenesis varies at different stages of the disease

we proposed that different targets should be targeted at different stages of the disease for an effective disease-modifying treatment.