Objective      To identify the profiles of coagulation ability and plasma platelet content in the first and third trimester women with pre-eclampsia (PE)

and investigate their clinical significance.       Methods      Totally 84 gravidas

including 24 diagnosed as mild PE and 19 as severe PE who gave birth in our department from November 2011 to October 2013 and were continuously followed up were enrolled in this study. Another 41 matched pregnant women hospitalized at the same period served as control. Their gestation ages

pregnancy

weeks

coagulation indexes

such as fibrinogen (FIB)

thrombin time (TT)

activated partial thromboplastin time (APTT)

D-dimer (D-D)

and prothrombin time (PT)

and platelet parameters

including plasma platelet count (PLT)

platelet distribution width (PDW)

mean platelet volume (MPV) and plateletcrit (PCT) were collected and retrospectively analyzed.       Results      The PE women at the third trimester had significantly decreased FIB than the normal control at the same trimester

but no such change was seen in those at the first trimester(

P

0.05). All women had obviously shorter APTT at the third than the first trimester (

P

0.05). All patients at the third trimester appeared lower PLT and increased MPV than them at the first trimester (

P

0.05). The severe PE patients also had longest TT

and highest D-D (above 2 000 μg/L) than the other groups (

P

0.05).        Conclusion      The PE patients at the third trimester present at a super-hypercoagulable state

which might be the pathological cause of multiple organ failure. The obvious increase of D-D is an early warning of eclampsia.