Objective       To investigate the brain structure and function in the patients of major depression disorder (MDD) by resting-state functional magnetic resonance imaging (fMRI) and fractional amplitude of low-frequency fluctuation (fALFF).       Methods       Ten identified MDD patients and 13 healthy controls who were matched with the patients in the age

gender and educational level were enrolled in this study. They were scanned with 3.0T MRI scanner. fALFF was used for the features of resting-state brain function

. The correlation of abnormal resting-state with behavioral inhibition/activation was investigated.       Results       MDD patients exhibited significantly higher fALFF in right cerebellum

left parahippacampus

left medial frontal gyrus

and obviously decreased fALFF in left median frontal gyrus

right superior frontal gyrus and right precental gyrus than the normal control (

P

0.05). In controls

fALFF of right cerebellum was negatively correlated with behavioral inhibition system (BIS

r=-0.647

P

=0.009)

and fALFF of left medial frontal gyrus was negatively correlated with behavioral activation system-drive (BASD

r=-0.593

P

=0.020). In MDD patients

fALFF of left median frontal gyrus was positively correlated with behavioral activation system-fun seeking (BASF

r=0.605

P

=0.049).       Conclusion       There exists abnormal fALFF pattern in MDD patients in default mode network and mood regulation circuit

with positive correlation with behavioral inhibition/activation.