Objective      To assess the clinic value of diffusion tensor imaging (DTI) combined with fluorescein sodium in guiding resection of gliomas in or near the eloquent region.       Methods      The data of patients with gliomas in or near the eloquent region treated in our hospital from February 2010 to June 2011 were retrospectively investigated. These patients followed up for at most 24 months were divided into 2 groups

an observation group and a control group. The 21 patients in the observation group underwent enhanced MRI and DTI before operation and were injected with fluorescein sodium during o

peration. The 22 patients in the control group only underwent enhanced MRI before operation. All patients were subjected to enhanced MRI to assess the degree of resection one day after the operation. Karnofsky score was used to evaluate all patients’ quality of life two weeks after the operation. All patients underwent chemoradiotherapy after operation for more than 3 months. Two-year survival rate of the patients was observed.       Results      The total tumor removal rate evaluated by enhanced MRI after operation

Karnofsky score in 2 weeks after operation and two-year survival rate in the observation group were all higher than those in the control group

with statistically significant differences (

P

0.05).       Conclusion      The application of DTI combined with fluorescein sodium helps achieve maximal glioma resection in or near the eloquent region and minimal damage of functional fiber bundles

improving patients’ quality of life and survival time.