Objective      To investigate the willingness and its influencing factors to participate in the clinical trials which take antiviral drugs to prevent HIV among the HIV-negative persons whose regular sexual partners were HIV-infected persons (PARs) in Sichuan and Xinjiang

China.        Methods      A cross-sectional survey was conducted and influencing factors were analyzed by univariate and multivariate logistic regression.        Results      Totally 396 qualified subjects were

recruited

of which 12.88% had ever heard and 85.86% were willing to participate in the clinical trials of HIV prevention. Household registration (rural/urban: AOR=4.269

P

=0.000 5)

self-awareness of HIV infection risk (high/low: AOR=2.509

P

=0.022 1; moderate/low: AOR=2.338

P

=0.048 4)

using condoms or not when having sex with HIV-infected partners in the nearly six months (not using/not having sex: AOR=10.451

P

=0.029 4)

and attitude to HIV-infected partners to medication (support/not support or unsure: AOR=2.079

P

=0.042 9) were screened by multivariate analysis.        Conclusion      The willingness is relatively high

which is affected by household registration

self-risk cognition and social support.