Volumetric modulated arc therapy with double arcs vs seven-field fixed-gantry dynamic intensity modulated radiotherapy in cervical cancer: a dosimetric study
Cui Tianxiang,Jin Junyu,Xu Yanmei,Dai Hongya,Sun Jianguo.Volumetric modulated arc therapy with double arcs vs seven-field fixed-gantry dynamic intensity modulated radiotherapy in cervical cancer: a dosimetric study[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(23):2569-2572.
Cui Tianxiang,Jin Junyu,Xu Yanmei,Dai Hongya,Sun Jianguo.Volumetric modulated arc therapy with double arcs vs seven-field fixed-gantry dynamic intensity modulated radiotherapy in cervical cancer: a dosimetric study[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(23):2569-2572.DOI:
Objective To compare the dosimetric difference between volumetric modulated arc therapy (VMAT) with double arcs and seven-field fixed-gantry dynamic intensity modulated radiotherapy (dIMRT) in the treatment of cervical cancer for the best plan of radiotherapy. Methods Based on the Varian r
adiation treatment planning system (Eclipse 8.6)
2 arcs of VMAT plans and 7 fields of dIMRT plans were generated in 10 patients with cervical cancer
respectively. Dose volume histograms were used to compare the target volume
normal tissue and organs at risks in the radiation field. Machine number (MU)
irradiation time and optimization time were evaluated to assess plan quality. Results Compared to dIMRT
conformity index (CI) of VMAT was closer to 1 (
P
0.05)
and D
100%
were significantly greater and D
min
were closer to the prescription dose (
P
0.05)
but there was no significant difference in evenness index(HI). D
mean
of caput femoris were significantly lower in VMAT than in dIMRT(
P
0.05)
while D
5%
was similar in the 2 planning. There was no difference in the protection of small intestine
bladder
rectum and cauda equine between VMAT and dIMRT
but the both of them reached the clinical requirement. The MU of VMAT was a quarter of that of dIMRT
and the treatment time was only a third of that of dIMRT. Conclusion Compared to the dIMRT
VAMT shows a better effect in target dose distribution
reduces the irradiation doses on organs at risk
and decreases the volume of high-dose area (20 to 30 Gy) in normal tissues
with the advantages of less MU and shorter overall treatment time. It is a better option for the development direction of cervical cancer radiotherapy.