Objective      To establish an animal model of intra-abdominal hypertension (IAH) followed by hemorrhagic shock and in

vestigate the features of the intra-abdominal pressure changes and the alteration of cardiorespiratory monitoring indicators.        Methods      Healthy adult experimental pigs were employed for bloodletting from the femoral artery till mean arterial pressure (MAP) to 50 mmHg for 1 h to reproduce hemorrhagic shock model. IAH model was successfully reproduced in 8 pigs by partial occlusion of portal vein. The pigs were randomly divided into treatment group (n=4) and control group (n=4). Intra-abdominal volume increment (IAVI) treatment was used to the rats of treatment group. Vesical pressure (VP) was observed before bleeding

in 1 h after bleeding

2 h after IAH and 12 h after IAVI treatment.        Results      With the gradual increase of intra-abdominal pressure

vesical pressure was increased in both groups (12±2 vs 27±8 cmH

2

O

P

0.01). After IAVI treatment

the pressure was reduced (27±8 vs 12±2 cmH

2

O

P

0.01)

and also had significant difference with that in the control (30±7 vs 12±2 cmH

2

O

P0.01). With the gradual formation of hemorrhagic shock

MAP was deceased from 115±9 to 62±13 mmHg (

P

0.01)

heart rate was increased from 55±4 to 118±17 beats/min (

P

0.01). Respiratory rate was significantly elevated with the increase of abdominal hypertension (59±9 vs 32±13 times/min

P

0.01). After treatment

the respiratory rate was significantly lower in the treatment group than the control group (33±4 vs 53±18 times/min，

P

0.01). Serum level of lactic acid after shock was significantly increased (1.9±0.8 vs 0.9±0.5 mmoL/L

P

0.01)

and was decreased after 12 hours’ treatment (1.0±0.4 vs 1.9±0.8 mmoL/L

P

0.01).        Conclusion      Our model is a good simulation of IAH secondary to traumatic hemorrhagic shock. With IAH formation

intra-abdominal hypertension is significantly increased. Abdominal decompression significantly reduces the pressure

improves breathing frequency

and lowers serum level of lactic acid.