Bacterial biofilms possess strong drug resistance and can evade from immune attack

resulting in chronic infection

which is difficult to control and can’t be effectively treated by conventional anti-infective therapy. In the searching of an effective drug therapeutic target for anti-biofilm

bacterial quorum sensing (QS) system has been attached great importance. QS system is an important signal regulatory system of bacterial cells

and participates in a large number of gene expressions. AI-2 QS system is widespread in gram-positive bacteria and gram-negative bacteria

which is the only currently-known intra- and inter-specific QS signal transduction system. The phenotypes of AI-2 QS system include luminescent effect

locomotory capacity

biofilm formation

and release of virulence factors. QS suppression system may inhibit bacterial biofilm formation and significantly affect the expression of bacterial toxin or virulence. This provides a new research direction for the prevention and control of bacterial biofilm infection. This article reviewed the progress of AI-2 QS system inhibitors and discussed its potential as a new anti-infective agent.