Objective      To study the relationship of hypothyroidism with depression and anxiety in peri-menopause women.       Methods      One hundred and thirteen women in peri-menopause period were divided into three groups including a normal control group (n=33)

a subclinical hypothyroidism group (n=

35) and an overt hypothyroidism group (n=78). The anxiety and depression of the subjects were investigated with self-rating anxiety scale (SAS) and self-rating depression scale (SDS). The correlation between thyroid hormones and anxiety/depression was observed.       Results      The prevalence of anxiety and depression in peri-menopause women with hypothyroidism was higher than that in the control group (

P

0.05). SAS scores had significantly negative correlation with free thyroxine (FT4) (

r

=-0.326

P

0.01) and positive correlation with thyroid stimulating hormone (TSH) (

r

=0.240

P0.01). SDS scores had significantly negative correlation with free triiodothyronine (FT3) and FT4 (

r

=-0.427

r

=-0.627

P

0.01) and positive correlation with thyroid stimulating hormone (TSH) (

r

=0.555

P

0.01).       Conclusion      The prevalence of anxiety and depression increases in peri-menopause women with hypothyroidism. There is significant correlation between the degree of anxiety/depression and thyroid hormone levels.