Objective        To observe the variation of high-amplitude slow waves in bedside video electroencephalogram (VEEG) of preterm infants between 28 and 30 weeks of conceptional age (CA)

and to explore the prognostic value and clinical significance.       Methods        Bedside VEEGs were recorded in 1 to 3 d after birth for all the p

remature infants between 28 and 30 weeks of CA

who hospitalized in the neonatal intensive care unit from August

2011 to May

2012. According to the CA

the premature infants were divided into 2 groups (28-29 weeks and 30 weeks)

and the two groups were subdivided into a survival group and a death group based on the prognosis. The 20-minute semi-quantitative analysis was carried out in the interburst interval duration (IBI) and the high-amplitude slow waves.       Results        The maximum IBI was significantly higher in the death group than in the survival group (

P

0.01). At 28 to 30 weeks of CA

high-amplitude slow waves of 150 to 300 μV are numerous and predominant in the temporal and occipital areas. The number of high-amplitude slow waves of 300 μV in the temporal and occipital areas and that in the frontal area at 30 weeks of CA were significantly higher in the death group than in the survival group (

P

0.05). Both deformed delta brushes and delta waves with superimposed high-voltage sharp activity had higher incidence and greater number in the death group than in the survival group (

P

0.05). The incidence of common deformed delta waves and the number of delta waves were greater in the death group than in the survival group as well (

P

0.05).       Conclusion        Prolonged IBI and excessive special deformed high-amplitude slow waves in the early bedside VEEG of preterm infants may relate to brain injury and poor prognosis.