Objective       To investigate the potential association between serum lipids and atrial

fibrillation (AF).       Methods        Five hundred and ninety-eight patients with AF including 295 patients with paroxysmal AF (PAF) and 303 patients with non-paroxysmal AF (NPAF) were enrolled

and 596 non-AF patients with hypertension and diabetes were served as control. Primary clinical and laboratory data including white blood cell count (WBC)

neutrophilic granulocyte ratio

liver function

blood lipids

blood glucose

renal function

thyroid function

electrocardiograph (ECG)/Holter-ECG and echocardiograph were collected in all patients. The changes of blood lipid levels in the AF group and sub-groups were compared with those of the control group.       Results       Compared with the control group

there were significant decreases in the levels of triglycerides (TG)

total cholesterol (TC)

high-density lipoprotein (HDL)

low-density lipoprotein (LDL)

apolipoprotein (Apo) A1

ApoB and left ventricular ejection fraction (LVEF) and significant increase in age

WBC count

neutrophilic granulocyte ratio and left atrium diameter (LAD) in the AF group (

P

0.05). The multivariate stepwise logistic regression analysis showed that WBC and LAD were positively correlated with atrial fibrillation (

OR

=1.119

P

0.05;

OR

=1.147

P

0.05)

while TG

HDL and LDL were negatively correlated with atrial fibrillation (OR=0.822

P

0.05;

OR

=0.401

P

0.05;

OR

=0.736

P

0.05). The regression analysis in the subgroups showed that HDL (

OR

=0.420

P0.05) and LDL (

OR

=0.695

P

0.05) were negatively correlated with PAF

but LAD (

OR

=1.0785

P

0.05) was positively correlated with PAF. Notably

HDL

LDL and TG (

OR

=0.219

P

0.05;

OR

=0.638

P0.05;

OR

=0.676

P

0.05) were negatively correlated with NPAF

and LAD (

OR

=1.247

P

0.05) was positively correlated with NAPF.       Conclusion       Blood lipids especially LDL and HDL levels are significantly lower in patients with AF

and are prone to decrease gra

dually with PAF progressing into chronic AF.