Objective      To investigate the effect of LED red-light radiation on promoting wound healing in mice with combined radiation-trauma injury.       Methods      C57BL/6 mice were randomly divided into a simple trauma group

a combined radiation-trauma injury group

and a combined radiation-trauma injury+LED red-light radiation group. Only a full-thickness skin defect wound was made on the back of mice in the simple trauma group. Before wound making

the mice in the combined radiation-trauma injury group underwent single-dose systematic radiation of

60

Coγ (5.0 Gy)

while the mice in the combined radiation-trauma in

jury+LED red-light radiation group were subjected to LED red-light radiation after wound making. The following parameters were analyzed: wound healing

changes of general status

body mass and blood routine

as well as temperature change in the radiation capsule during LED red-light radiation.       Results      All the wounds healed. The mean wound healing time in the combined radiation-trauma injury+LED red-light radiation group was shorter than that in the combined radiation-trauma injury group (by 1-2 d;

P

0.05)

and the ratio of WBC in peripheral blood was higher (by 43.41% on day 25 and by 37.98% on day 28;

P

0.05). No significant difference in body mass was observed between these two groups (P0.05).       Conclusion      Wound healing of combined radiation-trauma injury is delayed as compared with that of simple trauma

while LED red-light radiation can promote the process.