Objective      To explore the immune function of antigen epitope peptides based on MompS antigen of Legionella pneumophila serogroup 1(LP1).       Methods      The genetic information of LP1 MompS antigen was retrieved in GenBank by using bioinformatics software online. Combined with the prediction scheme theory of protein secondary structure by DNA Star

the B epitope antigen sites were predicted

and then the polypeptides which have the specific amino acid sequence of LP1 were synthesized. The binding ability of the obtained polypeptides to LP1 was detected by peptides binding assay and animal immunology effect assessment.       Results      Three obtained peptides

GP-15

NY-1

7 and AA-19 were screened out

and the GP-15 peptide had the best immunogenic ability among 3 peptides in the peptides binding assay (

P

0.05) and animal immuno-logy effect assessment (

P

0.05).       Conclusion      All of the 3 peptides are MompS antigen epitope peptides

and the GP-15 can be used to construct vaccine of Legionella pneumophila.