Objective       To evaluate the clinical efficacy and safety of transcatheter closure in treatment of giant coronary artery fistula.       Methods      Eight cases with giant coronary artery fistula treated with interventional occlusion treatment in our department during November 2006 to August 2010 were enrolled in this study. There were 5 males and 3 females

with an average age of 30.38±22.83 (ranging from 8 to 68). There were 4 cases of right coronary artery-right ventricular fistula (RCA-RV)

3 cases of right coronary artery-left ventricular fistula (RCA-LV)

and 1 case of left coronary artery-right atrial fistula (LCA-RA). They were followed up for an average time of 30.63±3.85 months (ranging from 24 to 36 months). Their clinical data before

during

in 1

3 and 6 months

and 1 and 2 years after operation were collected and analyzed as self-controlled trial.       Results       All patients were successfully treated with transcatheter occlusion. No heart murmur was found in all cases after closure. Coronary angiography and echocardiography found no residual shunt. Compared with before operation

the right ventricle

right atrium

left atrium and left ventricular were reduced significantly in size (P0.05)

and the left ventricular ejection fraction (LVEF) was improved conspicuously (P0.001). No complication related to transcatheter closure occurred.       Conclusion       Percutaneous closure is a safety and efficient approach in treatment of giant coronary artery fistula. It improves heart remodeling and heart functions.