Objective　　　 To determine the difference of the expression of TNFα-induced protein 3-interacting protein 1 (TNIP1) and its coding protein

A20-binding inhibitor of NF-κB activation (ABIN-1) between patients suffering from vulgaris psoriasis and health individuals in order to figure out the role of TNIP1 in the progress of vulgaris psoriasis.　　　 Methods　　　 Twenty-five psoriasis patients (13 males and 12 f

emales

mean age of 33.0±8.3) admitted to our department from October 2011 to April 2012 were enrolled. Twenty-five healthy control subjects (14 males and 11 females

mean age of 31.3±9.9) were subjected from the department of physical examination of our hospital. There was no significant difference between these 2 groups in age or gender. The mRNA expression of TNIP1 and the expression of its translational protein ABIN1 in the peripheral lymphocyte were detected by QRT-PCR and Western blotting. Immunohistochemical assay was also employed to study the expression of ABIN1 in the skin.　　　 Results　　　 The expression of TNIP1 mRNA in the peripheral lymphocyte was notably lower in vulgaris psoriasis group than the healthy control (0.292 1±0.101 6 vs 1.0859±0.266 3

P0.05). The expression of ABIN1 in the peripheral lymphocyte was also remarkably lower in vulgaris psoriasis group（0.093 2±0.003 9）than the healthy group (0.290 9±0.057 8

P

0.05). Besides

ABIN1 protein was over-expressed in the epidermis and mainly in the extranuclear in normal skin

but its expression level was very low in skin lesion of patients.　　　 Conclusion　　　 Mild expression of TNIP1 and ABIN1 might be related to the pathogenesis of vulgaris psoriasis.