Objective        To understand the willingness to participate in pre-exposure prophylaxis (PrEP) clinical trial and the influencing factors among female sex workers (FSWs) in Chongqing

Sichuan

Guangxi and Xinjiang.       Methods        Face-to-face anonymous questionnaire was conducted in 1 340 qualified objects by non-randomly sampling method.   Chi square test was employed to conduct univariate analysis

and multivariate analysis was conducted using logistic regression.       Results       The awareness rate of PrEP among FSWs was 15.27% and elevated to 56.49% after being taught on PrEP-related knowledge by investigators. Logistic regression showed that the factors influencing the willingness to participate PrEP clinical trial among FSWs were survey sites (Sichuan/Guangxi: OR=0.471

P=0.000 1; Xinjiang/Guangxi: OR=1.971

P0.01)

self-awareness of difficulty in preventing AIDS (not difficult/difficult: OR=1.507

P=0.009 0)

whether offering to use condoms or not (yes/no: OR=1.645

P=0.014 5)

whether refusing to have sex or not if the male did not use condoms (yes/no: OR=1.506

P=0.008 8)

whether should promoting PrEP in female sex workers or not (yes/no: OR=2.105

P0.01)

and whether would recommending friends to use PrEP or not (yes/no: OR=1.642

P=0.035 9).       Conclusion        The willingness to participate in PrEP clinical trial among FSWs in Chongqing

Sichuan

Guangxi and Xinjiang are relatively high.