Objective      To investigate the effects of hemoperfusion combined with hemodialysis in the treatment of drug-induced liver injury.       Methods      Ten drug-induced liver injury patients with severe jaundice hospitalized in our department from December 2010 to November 2011 were randomly divided into control group (C group)

hemoperfusion combined with hemodialysis (HP+HD) group

with each group having 5 cases. The control group underwent conventional therapy

and the HP+HD group was treated with hemoperfusion combined with hemodialysis one or two times in the first week besides conventional therapy. Then the levels of serum total bilirubin (TBIL) were measured before and at 7

14 and 30 d after treatment

and the decline levels of TBIL were also compared between the above groups at different time points.       Results      TBIL was 464.7±127.7

181.3±49.8

111.5±45.8 and 28.4±10.5 respectively，in HP+HD group before and at 7

14 and 30 d after treatment

while that was 373.2±65.8

363.4±165.6

256.4±131.1

and 75.2±43.3 respectively in C group at the corresponding time points. TBIL level of HP+HD group was significantly decreased at day 14 after treatment when compared with that of C group (P0.05). The decline of TBIL level was 283.4±156.5

353.2±136.4

and 436.4±134.6 respectively in HP+HD group at 7

14 and 30 d after treatment

that of C group was 9.8±132.4

116.7±103.2 and 297.9±51.3 respectively

with the former group obviously higher than the later at days 7 and 14 (P0.05).       Conclusion      HP+HD treatment promotes the cleanup of TBIL in drug-induced liver injury patients and improve the liver function. The patients may benefit a lot from the HP+HD application in the early stage of drug-induced liver injury.