Objective        To investigate the symptom burden and quality of life in hemodialysis patients

and to analyze the influencing factors of symptom burden and their correlation with the quality of life.       Methods        Totally 136 patients receiving hemodialysis from two 3 grade-A hospitals in Chongqing were investigated with general information questionnaire

dialysis frequency

severity and symptom burden index (DFSSBI) as well as MOS 36-item short form health survey (SF-36).       Results        The scores of symptom burden and quality of life in all the hemodialysis patients were 75.63±32.25 and 53.32±16.80

respectively. The multivariate stepwise regression analysis showed the symptom burden was statistically significantly correlated with the income

work status

age and sex of the patients (P0.05). Pearson correlation analysis demonstrated that the symptom burden score was negatively correlated with the scores of physical function

physical role

bodily pain

general health

vitality

social function

emotional role and mental health (r=-0.94 to -0.48).       Conclusion        Patients receiving hemodialysis have different levels of symptom burden

and their impaired quality of life need to be improved in the future. More attention should be given to the assessment and management of symptom burden to improve the quality of life of hemodialysis patients.